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National smoking research trial recruiting Stoke mums-to-be

By Liana Snape   31st Oct 2025

Lisa Peake, tobacco dependency practitioner at UHNM (image via UHNM)
Lisa Peake, tobacco dependency practitioner at UHNM (image via UHNM)

A national research trial, designed to make it easier to stop smoking during pregnancy, is being conducted at University Hospitals of North Midlands NHS Trust (UHNM). 

Mums-to-be are being encouraged to take part in the SNAP-3 trial, which will explore how to improve the use of nicotine replacement therapy (NRT) as a stop smoking aid for pregnant women.  

The study, funded by the National Institute for Health and Care Research (NIHR) and led nationally by the University of Nottingham, will randomly allocate participants to one of two treatments. 

Participants will receive either the current gold-standard NHS stop smoking support, including NRT, or the same support with additional telephone coaching and advice. 

SNAP-3, which aims to recruit 1,430 women nationally, is open to women who are less than 25 weeks pregnant and smoke five or more cigarettes a day.  

Dr Angela Hancock, consultant midwife for public health, NIHR senior research leader and principal investigator for the SNAP-3 study at UHNM, said: "Stopping smoking in pregnancy is one of the best things a woman and her family can do for a baby's long-term health. 

"The NHS already offers NRT free of charge to pregnant women and their families, and this study aims to understand whether enhanced ways of using it can help more women quit successfully. 

"The aim of the SNAP-3 study is to test how effective nicotine replacement therapy can be when paired with enhanced behavioural support. 

"We want to improve the ways we help pregnant women to use NRT confidently, giving them the best chance of stopping smoking. 

"We hope to identify and invite women early in their pregnancy, either at their booking appointment or dating scan, so they can receive support as soon as possible.  

"Participants will then be allocated to either the usual NHS support or the SNAP-3 intervention, which takes a slightly different approach to using NRT to encourage stopping smoking." 

     

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